Science Reviews - Biology, 2025, 4(1), 8-14 Irfan Sajid, Shoaib Ahmed et al.
1
Antioxidant effects following oral administration of
Foeniculum vulgare
in male rats
Irfan Sajid, PhD
1
*, Shoaib Ahmed, PhD
1
, Lubna Anis, M.Phil.
1
, Hafsah Khan,
M.Phil.
1
, Syed Ikhlaq Hussain, PhD
2
1
Department of Biochemistry, Federal Urdu University of Arts, Science and Technology, Karachi
2
Department of Zoology, Federal Urdu University of Arts, Science and Technology, Karachi
*Corresponding Author: Irfan Sajid (irfan.sajid@fuuast.edu.pk)
https://orcid.org/0000-0002-5547-3492
References
1. Yang, I. J., Lee, D. U., & Shin, H. M. (2015). Antiinflammatory and antioxidant effects of coumarins
isolated from Foeniculum vulgare in lipopolysaccharidestimulated macrophages and 12Otetradeca-
noylphorbol13acetatestimulated mice. Immunopharmacology and Immunotoxicology, 37, 308317.
2. Manzoor, A., Rather, B. A. D., Shahnawaz, N. S., Bilal, A. B., Mushtaq, A., & Qurishi, A. (2016).
Foeniculum vulgare: A comprehensive review of its traditional use, phytochemistry, pharmacology,
and safety. Arabian Journal of Chemistry, 9, 15741583.
3. Hina, B., Aamir, S., Kanza, S., Masood, S. B., Saira, T., Tayyaba, I., & Ushnah, S. (2014). Composi-
tional profiling of fennel seed. Pakistan Journal of Food Science, 24(3), 132136.
4. Patel, K., & Srinivasan, K. (2001). Studies on the influence of dietary spices on food transit time in
experimental rats. Agricultural and Food Sciences, Nutritional Research, 21(9), 13091314.
5. Noreen, S., Tufail, T., Badar Ul Ain, H., & Awuchi, C. G. (2023). Pharmacological, nutraceutical,
functional, and therapeutic properties of fennel (Foeniculum vulgare). International Journal of Food Prop-
erties, 26(1), 915927.
6. Razieh, B., Seyed, H. A., Abolfazl, M., Fatemeh, A., Akram, A., Ahmad, H., Hosein, M. D., Farhad,
H., & Majid, A. (2022). Effects of Iranian polyherbal syrup (Zufa syrup) on oxygen saturation and
clinical symptoms in suspected patients with COVID-19: A triple-blinded, randomized, placebo-con-
trolled trial. Medical Gas Research, 12(2), 4450.
7. Anand, P., Kunnumakara, A., Sundaram, C., Harikumar, K., Tharakan, S., Lai, O., Sung, B., &
Aggarwal, B. (2008). Cancer is a preventable disease that requires major lifestyle changes. Pharmaceu-
tical Research, 25, 20972116.
8. Chainy, G. B., Manna, S. K., Chaturvedi, M. M., & Aggarwal, B. B. (2000). Anethole blocks both
early and late cellular responses transduced by tumor necrosis factor: Effect on NF-kappaB, AP-1,
JNK, MAPKK, and apoptosis. Oncogene, 19(25), 29432950.
9. Süntar, I. (2019). Importance of ethnopharmacological studies in drug discovery: Role of medicinal
plants. Phytochemistry Reviews. Corpus ID: 203875447.
10. Anwar, F., Ali, M., Hussain, A. I., & Shahid, M. (2009). Antioxidant and antimicrobial activities
of essential oil and extracts of fennel (Foeniculum vulgare Mill.) seeds from Pakistan. Flavour and Fra-
grance Journal, 24, 170176.
Irfan Sajid, Shoaib Ahmed et al. Science Reviews - Biology, 2025, 4(1), 8-14
2
11. Goto, Y., Watanabe, N., Kogawa, N., Tsuchiya, M., Takahashi, O., & Uchi, H. (2002). European
Journal of Pharmacology, 438, 189192.
12. Bhatti, S. A., Shah, S. A., Ahmed, T., & Zahid, S. (2018). Neuroprotective effects of Foeniculum
vulgare seeds extract on lead-induced neurotoxicity in mice brain. Drug and Chemical Toxicology, 41(4),
399407.
13. Sushruta, K., & Hemant, K. (2003). Foeniculum vulgare Mill (Umbelliferae) attenuates stress and
improves memory in Wistar rats. Tropical Journal of Pharmaceutical Research, 12(4), 553558.
14. Irfan, S., Saara, A., Shaista, E., Zehra, B., Saima, K., Lubna, A., Saiqa, T., Syeda, M., Laraib, L.,
Sadia, S., Tahira, P., & Saida, H. (2017). Enhanced physical endurance and improved memory perfor-
mance following taurine administration in rats. Pakistan Journal of Pharmaceutical Sciences, 30(5 Sup-
plementary), 19571963.
15. Oktay, M., Gülin, I., & Küfreviolu, O. (2003). Determination of in vitro antioxidant activity of
fennel (Foeniculum vulgare) seed extracts. Lebensmittel-Wissenschaft & Technologie, 36(2), 263271.
16. Ahmed, A. F., Shi, M., Liu, C., & Kang, W. (2019). Comparative analysis of antioxidant activities
of essential oils and extracts of fennel (Foeniculum vulgare Mill.) seeds from Egypt and China. Food
Science and Human Wellness, 8, 6772.
17. Hassan, B., Ibrahim, A. A., Sami, A. A., Hani, A. A., Raghad, M. A., Mona, S. A., Raya, S. A.,
Taqwa, B., & Ahmed, M. (2023). Nephroprotective effect of fennel (Foeniculum vulgare) seeds and their
sprouts on CCl-induced nephrotoxicity and oxidative stress in rats. Antioxidants, 12(2), 325.
18. Ali, A., Riaz, S., Sameen, A., Naumovski, N., Iqbal, M. W., Rehman, A., Mehany, T., Zeng, X.-A.,
& Manzoor, M. F. (2022). The disposition of bioactive compounds from fruit waste, their extraction,
and analysis using novel technologies: A review. Processes, 10(10), 2014.
19. Manzoor, M. F., Hussain, A., Tazeddinova, D., Abylgazinova, A., & Xu, B. (2022). Assessing the
nutritional-value-based therapeutic potentials and non-destructive approaches for mulberry fruit as-
sessment: An overview. Computational Intelligence and Neuroscience, 6531483.
20. Irene, P., Olga, J., Ferran, S., Francesc, V., Jaume, B., & Carles, C. (2004b). Separation and charac-
terization of phenolic compounds in fennel (Foeniculum vulgare) using liquid chromatography: Neg-
ative electrospray ionization tandem mass spectrometry. Journal of Agricultural and Food Chemistry, 52,
36793687.
21. Sura, S., Khafaji, A., Ghazi, H., Hasan, M. A., Mer, A., Mohanad, O., Abdullah, A. J., & Ahmed, F.
F. (2024). Study of the effects of Foeniculum vulgare on serological and biochemical traits in broiler
chicks. Minar International Conference (ISBN: 978-605-73233-4-7).
22. Nickavar, B., & Abolhasani, F. A.-S. (2009). Screening of antioxidant properties of seven Umbel-
liferae fruits from Iran. Pakistan Journal of Pharmaceutical Sciences, 22, 3035.
23. Rezq, A. (2013). Beneficial health effects of fennel seeds (Shamar) on male rats feeding a high-fat
diet.
24. Zayachkivska, O. S., Konturek, S. J., Drozdowicz, D., Konturek, P. C., Brzozowski, T., & Ghegot-
sky, M. R. (2005). Gastroprotective effects of flavonoids in plant extracts. Journal of Physiology and
Pharmacology, 56(Suppl 1), 219231.
25. Ragaa, H., Mohamad, A., Mohamad, E. B., Mohamad, G. M., Assmaa, M. N., Hussain, A. R.,
Mehdar, A., Sabry, M. S., & Mahmuod, M. E. M. (2011). Antioxidant and anticarcinogenic effects of
methanolic extract and volatile oil of fennel seeds (Foeniculum vulgare). Journal of Medicinal Food, 14(9),
9861001.
Science Reviews - Biology, 2025, 4(1), 8-14 Irfan Sajid, Shoaib Ahmed et al.
3
26. Choi, E. M., & Hwang, J. K. (2004). Anti-inflammatory, analgesic, and antioxidant activities of the
fruit of Foeniculum vulgare. Fitoterapia, 75, 557565.
27. Hossein, K., Mehdi, S., & Roja, R. (2016). A sustained-release dosage form for respiratory disor-
ders in traditional Persian medicine. Journal of Evidence-Based Complementary and Alternative Medicine,
21(1), 6370.