Science Reviews - Biology, 2024, 3(1), 1-8 Muhammad Tahir Hayat
The Role of Non-Coding RNAs in Cancer Progression:
A Concise Comprehensive Review
Muhammad Tahir Hayat, PhD.
Department of Biotechnology, Faculty of Biological Sciences, Quaid-i-Azam University, 45320, Islamabad, Pakistan;
tahirhayatpk@yahoo.com
https://orcid.org/0000-0001-9304-9425
https://doi.org/10.57098/SciRevs.Biology.3.1.1
Received February 28, 2024. Revised March 17, 2024. Accepted March 18, 2024.
References
1. Aguilo, F., Di Cecilia, S., & Walsh, M. J. (2016). Long non-coding RNA ANRIL and polycomb in
human cancers and cardiovascular disease. Long Non-Coding RNAs in Human Disease, 2939.
2. Anastasiadou, E., Faggioni, A., Trivedi, P., & Slack, F. J. (2018). The nefarious nexus of noncoding
RNAs in cancer. International Journal of Molecular Sciences, 19(7), 2072.
3. Anastasiadou, E., Jacob, L. S., & Slack, F. J. (2018). Non-coding RNA networks in cancer. Nature
Reviews Cancer, 18(1), 518.
4. Autin, P., Blanquart, C., & Fradin, D. (2019). Epigenetic drugs for cancer and microRNAs: a focus
on histone deacetylase inhibitors. Cancers, 11(10), 1530.
5. Birney, E., Stamatoyannopoulos, J. A., Dutta, A., Guigó, R., Gingeras, T. R., Margulies, E. H., Weng,
Z., Snyder, M., Dermitzakis, E. T., Stamatoyannopoulos, J. A., Thurman, R. E., Kuehn, M. S., Taylor,
C. M., Neph, S., Koch, C. M., Asthana, S., Malhotra, A., Adzhubei, I., Greenbaum, J. A., … Elements,
T. R. (2007). Identification and analysis of functional elements in 1% of the human genome by the
ENCODE pilot project. Nature, 447(7146), 799816. https://doi.org/10.1038/nature05874
6. Budakoti, M., Panwar, A. S., Molpa, D., Singh, R. K., Büsselberg, D., Mishra, A. P., Coutinho, H.
D. M., & Nigam, M. (2021). Micro-RNA: the darkhorse of cancer. Cellular Signalling, 83, 109995.
7. Calin, G. A., & Croce, C. M. (2006). MicroRNAs and chromosomal abnormalities in cancer cells.
Oncogene, 25(46), 62026210.
8. Calin, G. A., Dumitru, C. D., Shimizu, M., Bichi, R., Zupo, S., Noch, E., Aldler, H., Rattan, S.,
Keating, M., & Rai, K. (2002). Frequent deletions and down-regulation of micro-RNA genes miR15
and miR16 at 13q14 in chronic lymphocytic leukemia. Proceedings of the National Academy of Sciences,
99(24), 1552415529.
9. Chang, T.-C., Yu, D., Lee, Y.-S., Wentzel, E. A., Arking, D. E., West, K. M., Dang, C. V, Thomas-
Tikhonenko, A., & Mendell, J. T. (2008). Widespread microRNA repression by Myc contributes to
tumorigenesis. Nature Genetics, 40(1), 4350.
10. Chen, B., Dragomir, M. P., Fabris, L., Bayraktar, R., Knutsen, E., Liu, X., Tang, C., Li, Y., Shimura,
T., & Ivkovic, T. C. (2020). The long noncoding RNA CCAT2 induces chromosomal instability
through BOP1-AURKB signaling. Gastroenterology, 159(6), 21462162.
11. Chen, B., Zhang, R. N., Fan, X., Wang, J., Xu, C., An, B., Wang, Q., Wang, J., Leung, E. L.-H., & Sui,
X. (2020). Clinical diagnostic value of long non-coding RNAs in Colorectal Cancer: A systematic
review and meta-analysis. Journal of Cancer, 11(18), 5518.
12. Chen, L.-L. (2020). The expanding regulatory mechanisms and cellular functions of circular
RNAs. Nature Reviews Molecular Cell Biology, 21(8), 475490.
Muhammad Tahir Hayat Science Reviews - Biology, 2024, 3(1), 1-8
13. Cheng, Y. Q., Wang, S. B., Liu, J. H., Jin, L., Liu, Y., Li, C. Y., Su, Y. R., Liu, Y. R., Sang, X., & Wan,
Q. (2020). Modifying the tumour microenvironment and reverting tumour cells: New strategies for
treating malignant tumours. Cell Proliferation, 53(8), e12865.
14. Chiu, H.-S., Somvanshi, S., Patel, E., Chen, T.-W., Singh, V. P., Zorman, B., Patil, S. L., Pan, Y.,
Chatterjee, S. S., & Caesar-Johnson, S. J. (2018). Pan-cancer analysis of lncRNA regulation supports
their targeting of cancer genes in each tumor context. Cell Reports, 23(1), 297312.
15. Choudhari, R., Sedano, M. J., Harrison, A. L., Subramani, R., Lin, K. Y., Ramos, E. I.,
Lakshmanaswamy, R., & Gadad, S. S. (2020). Long noncoding RNAs in cancer: from discovery to
therapeutic targets. Advances in Clinical Chemistry, 95, 105147.
16. Di Leva, G., & Croce, C. M. (2013). miRNA profiling of cancer. Current Opinion in Genetics &
Development, 23(1), 311.
17. Ding, H., Zhang, L., Yang, Q., Zhang, X., & Li, X. (2021). Chapter Five - Epigenetics in kidney diseases
(G. S. B. T.-A. in C. C. Makowski (ed.); Vol. 104, pp. 233297). Elsevier.
https://doi.org/https://doi.org/10.1016/bs.acc.2020.09.005
18. Dozmorov, M. G., Giles, C. B., Koelsch, K. A., & Wren, J. D. (2013). Systematic classification of
non-coding RNAs by epigenomic similarity. BMC Bioinformatics, 14, 112.
19. Dragomir, M. P., Knutsen, E., & Calin, G. A. (2022). Classical and noncanonical functions of
miRNAs in cancers. Trends in Genetics, 38(4), 379394.
20. Eichmüller, S. B., Osen, W., Mandelboim, O., & Seliger, B. (2017). Immune modulatory
microRNAs involved in tumor attack and tumor immune escape. JNCI: Journal of the National Cancer
Institute, 109(10), djx034.
21. Esquela-Kerscher, A., & Slack, F. J. (2006). OncomirsmicroRNAs with a role in cancer. Nature
Reviews Cancer, 6(4), 259269.
22. Feng, J., Chen, K., Dong, X., Xu, X., Jin, Y., Zhang, X., Chen, W., Han, Y., Shao, L., & Gao, Y.
(2019). Genome-wide identification of cancer-specific alternative splicing in circRNA. Molecular
Cancer, 18(1), 15.
23. Grolmusz, V. K., Kövesdi, A., Borka, K., Igaz, P., & Patócs, A. (2018). Prognostic relevance of
proliferation-related miRNAs in pancreatic neuroendocrine neoplasms. European Journal of
Endocrinology, 179(4), 219228.
24. Hata, A., & Kashima, R. (2016). Dysregulation of microRNA biogenesis machinery in cancer.
Critical Reviews in Biochemistry and Molecular Biology, 51(3), 121134.
25. Hayes, J., Peruzzi, P. P., & Lawler, S. (2014). MicroRNAs in cancer: biomarkers, functions and
therapy. Trends in Molecular Medicine, 20(8), 460469.
26. Hua, Q., Lv, X., Gu, X., Chen, Y., Chu, H., Du, M., Gong, W., Wang, M., & Zhang, Z. (2016).
Genetic variants in lncRNA H19 are associated with the risk of bladder cancer in a Chinese
population. Mutagenesis, 31(5), 531538.
27. Huang, X., Yuan, T., Tschannen, M., Sun, Z., Jacob, H., Du, M., Liang, M., Dittmar, R. L., Liu, Y.,
& Liang, M. (2013). Characterization of human plasma-derived exosomal RNAs by deep sequencing.
BMC Genomics, 14(1), 114.
28. Hung, C.-L., Wang, L.-Y., Yu, Y.-L., Chen, H.-W., Srivastava, S., Petrovics, G., & Kung, H.-J.
(2014). A long noncoding RNA connects c-Myc to tumor metabolism. Proceedings of the National
Academy of Sciences, 111(52), 1869718702.
29. Jin, K., Wang, S., Zhang, Y., Xia, M., Mo, Y., Li, X., Li, G., Zeng, Z., Xiong, W., & He, Y. (2019).
Long non-coding RNA PVT1 interacts with MYC and its downstream molecules to synergistically
promote tumorigenesis. Cellular and Molecular Life Sciences, 76, 42754289.
Science Reviews - Biology, 2024, 3(1), 1-8 Muhammad Tahir Hayat
30. Liu, M., Jia, J., Wang, X., Liu, Y., Wang, C., & Fan, R. (2018). Long non-coding RNA HOTAIR
promotes cervical cancer progression through regulating BCL2 via targeting miR-143-3p. Cancer
Biology & Therapy, 19(5), 391399.
31. López-Urrutia, E., Bustamante Montes, L. P., Ladrón de Guevara Cervantes, D., Pérez-Plasencia,
C., & Campos-Parra, A. D. (2019). Crosstalk between long non-coding RNAs, micro-RNAs and
mRNAs: deciphering molecular mechanisms of master regulators in cancer. Frontiers in Oncology, 9,
669.
32. Luo, M.-L. (2016). Methods to study long noncoding RNA biology in cancer. The Long and Short
Non-Coding RNAs in Cancer Biology, 69107.
33. Moteki, S., & Price, D. (2002). Functional coupling of capping and transcription of mRNA.
Molecular Cell, 10(3), 599609.
34. Ni, Z., Wang, X., Zhang, T., Li, L., & Li, J. (2018). Comprehensive analysis of differential
expression profiles reveals potential biomarkers associated with the cell cycle and regulated by p53
in human small cell lung cancer. Experimental and Therapeutic Medicine, 15(4), 32733282.
35. Rheinbay, E., Parasuraman, P., Grimsby, J., Tiao, G., Engreitz, J. M., Kim, J., Lawrence, M. S.,
Taylor-Weiner, A., Rodriguez-Cuevas, S., & Rosenberg, M. (2017). Recurrent and functional
regulatory mutations in breast cancer. Nature, 547(7661), 5560.
36. Romano, G., Saviana, M., Le, P., Li, H., Micalo, L., Nigita, G., Acunzo, M., & Nana-Sinkam, P.
(2020). Non-coding RNA editing in cancer pathogenesis. Cancers, 12(7), 1845.
37. Romano, G., Veneziano, D., Nigita, G., & Nana-Sinkam, S. P. (2018). RNA methylation in ncRNA:
classes, detection, and molecular associations. Frontiers in Genetics, 9, 243.
38. Rupaimoole, R., & Slack, F. J. (2017). MicroRNA therapeutics: towards a new era for the
management of cancer and other diseases. Nature Reviews Drug Discovery, 16(3), 203222.
39. Shatkin, A. J., & Manley, J. L. (2000). The ends of the affair: capping and polyadenylation. Nature
Structural Biology, 7(10), 838842.
40. Siegel, R. L., Miller, K. D., & Jemal, A. (2019). Cancer statistics, 2019. CA: A Cancer Journal for
Clinicians, 69(1), 734.
41. Slack, F. J., & Chinnaiyan, A. M. (2019). The role of non-coding RNAs in oncology. Cell, 179(5),
10331055.
42. Svoronos, A. A., Engelman, D. M., & Slack, F. J. (2016). OncomiR or tumor suppressor? The
duplicity of microRNAs in cancer. Cancer Research, 76(13), 36663670.
43. Uppaluri, K. R., Challa, H. J., Gaur, A., Jain, R., Krishna Vardhani, K., Geddam, A., Natya, K.,
Aswini, K., Palasamudram, K., & K, S. M. (2023). Unlocking the potential of non-coding RNAs in
cancer research and therapy. Translational Oncology, 35(July), 101730.
https://doi.org/10.1016/j.tranon.2023.101730
44. Wang, S., Liang, K., Hu, Q., Li, P., Song, J., Yang, Y., Yao, J., Mangala, L. S., Li, C., & Yang, W.
(2017). JAK2-binding long noncoding RNA promotes breast cancer brain metastasis. The Journal of
Clinical Investigation, 127(12), 44984515.
45. Wang, Y., & Lee, C. G. L. (2009). MicroRNA and cancerfocus on apoptosis. Journal of Cellular and
Molecular Medicine, 13(1), 1223.
46. Xiong, T., Li, J., Chen, F., & Zhang, F. (2019). PCAT-1: a novel oncogenic long non-coding RNA in
human cancers. International Journal of Biological Sciences, 15(4), 847.
47. Yu, Y., Xiao, J., & Hann, S. S. (2019). The emerging roles of PIWI-interacting RNA in human cancers.
Cancer Management and Research, 58955909.
Muhammad Tahir Hayat Science Reviews - Biology, 2024, 3(1), 1-8
48. Zhang, P., Wu, W., Chen, Q., & Chen, M. (2019). Non-coding RNAs and their integrated networks.
Journal of Integrative Bioinformatics, 16(3), 20190027.
49. Zhang, W., Xia, W., Lv, Z., Ni, C., Xin, Y., & Yang, L. (2017). Liquid biopsy for cancer: circulating
tumor cells, circulating free DNA or exosomes? Cellular Physiology and Biochemistry, 41(2), 755768.
50. Zhao, M., Wang, S., Li, Q., Ji, Q., Guo, P., & Liu, X. (2018). MALAT1: A long non-coding RNA
highly associated with human cancers. Oncology Letters, 16(1), 1926.
51. Zhao, Y., Zhou, J., Wang, L., He, H., Wang, X., Tao, Z., Sun, H., Wu, W., Fan, J., & Tang, Z. (2012).
HIWI is associated with prognosis in patients with hepatocellular carcinoma after curative resection.
Cancer, 118(10), 27082717.