Science Reviews - Biology, 2023, 2(2), 30 - 39 Raquel Rodrigues
Möse, J. R., & Möse, G. (1964). Oncolysis by clostridia. I. Activity of Clostridium butyricum (M-55)
and other nonpathogenic clostridia against the Ehrlich carcinoma. Cancer Research, 24(2 Part 1), 212-
216. Retrieved from http://cancerres.aacrjournals.org/content/24/2_Part_1/212.abstract.
Mowday, A. M., Dubois, L. J., Kubiak, A. M., Chan-Hyams, J. V. E., Guise, C. P., Ashoorzadeh, A., . . .
Patterson, A. V. (2022). Use of an optimised enzyme/prodrug combination for Clostridia directed
enzyme prodrug therapy induces a significant growth delay in necrotic tumours. Cancer Gene Ther-
apy, 29(2), 178-188. https://doi.org/10.1038/s41417-021-00296-7.
Napoli, F., Olivieri, G., Russo, M. E., Marzocchella, A., & Salatino, P. (2010). Butanol production by
Clostridium acetobutylicum in a continuous packed bed reactor. Journal of Industrial Microbiology
& Biotechnology, 37(6), 603-608. https://doi.org/10.1007/s10295-010-0707-8.
Parker, R. C., Plummer, H. C., Siebenmann, C. O., & Chapman, M. G. (1947). Effect of histolyticus
infection and toxin on transplantable mouse tumors. Proceedings of the Society for Experimental Bi-
ology and Medicine, 66(2), 461-467. Retrieved from https://jour-
nals.sagepub.com/doi/abs/10.3181/00379727-66-16124. https://doi.org/10.3181/00379727-66-
16124
Pokrovsky, V. S., Anisimova, N. Y., Davydov, D. Z., Bazhenov, S. V., Bulushova, N. V., Zavilgelsky,
G. B., . . . Manukhov, I. V. (2019). Methionine gamma lyase from Clostridium sporogenes increases
the anticancer efficacy of doxorubicin on A549 cancer cells in vitro and human cancer xenografts. In
R. M. Hoffman (Ed.), Methionine Dependence of Cancer and Aging: Methods and Protocols (pp. 243-
261). New York, NY: Springer New York.
Rautio, J., Kumpulainen, H., Heimbach, T., Oliyai, R., Oh, D., Jarvinen, T., & Savolainen, J. (2008).
Prodrugs: design and clinical applications. Nat Rev Drug Discov, 7(3), 255-270.
https://doi.org/10.1038/nrd2468
Roberts, N. J., Zhang, L., Janku, F., Collins, A., Bai, R. Y., Staedtke, V., . . . Zhou, S. (2014). Intratumoral
injection of Clostridium novyi-NT spores induces antitumor responses. Sci Transl Med, 6(249),
249ra111. https://doi.org/10.1126/scitranslmed.3008982
Setlow, P. (2003). Spore germination. Current Opinion in Microbiology, 6(6), 550-556. Retrieved from
http://www.sciencedirect.com/science/article/pii/S1369527403001371.
https://doi.org/10.1016/j.mib.2003.10.001
Setlow, P. (2007). I will survive: DNA protection in bacterial spores. Trends in Microbiology, 15(4),
172-180. Retrieved from http://www.sciencedirect.com/science/article/pii/S0966842X07000261.
https://doi.org/10.1016/j.tim.2007.02.004
Siegel, R. L., Miller, K. D., Wagle, N. S., & Jemal, A. (2023). Cancer statistics, 2023. Ca: A Cancer Jour-
nal For Clinicians, 73(1), 17-48. Retrieved from https://acsjournals.onlineli-
brary.wiley.com/doi/abs/10.3322/caac.21763. https://doi.org/10.3322/caac.21763
Staedtke, V., Bai, R.-Y., Sun, W., Huang, J., Kibler, K. K., Tyler, B. M., . . . Riggins, G. J. (2015). Clos-
tridium novyi -NT can cause regression of orthotopically implanted glioblastomas in rats. Oncotar-
get, 6(8). Retrieved from https://www.oncotarget.com/article/3627/text/.
Staedtke, V., Gray-Bethke, T., Liu, G., Liapi, E., Riggins, G. J., & Bai, R. Y. (2022). Neutrophil depletion
enhanced the Clostridium novyi-NT therapy in mouse and rabbit tumor models. Neurooncol Adv,
4(1), vdab184. https://doi.org/10.1093/noajnl/vdab184
Tharmalingham, H., & Hoskin, P. (2019). Clinical trials targeting hypoxia. Br J Radiol, 92(1093),
20170966. https://doi.org/10.1259/bjr.20170966
Thiele, E. H., Arison, R. N., & Boxer, G. E. (1964). Oncolysis by clostridia. III. Effects of clostridia and
chemotherapeutic agents on rodent tumors. Cancer Research, 24(2 Part 1), 222-233. Retrieved from
http://cancerres.aacrjournals.org/content/24/2_Part_1/222.abstract.